By David E Elder, Rosalie Elenitsas, Michael D Ioffreda, Bernett L Johnson, Jeffrey J Miller

In line with Lever's Histopathology of the outside, 9th version, this full-color atlas offers an algorithmic development acceptance method of differential prognosis of epidermis ailments. while Lever's classifies ailments by means of pathogenesis, this atlas aids in differential analysis of unknown instances by way of classifying illnesses morphologically, in keeping with their situation within the epidermis and the styles and telephone forms visible during the microscope. inside of each one morphologic classification, prototypic issues are defined and illustrated with full-color photomicrographs, and an inventory of differential diagnostic probabilities is gifted. The atlas includes over 1,300 full-color illustrations. A bound-in photo financial institution CD-ROM includes the entire book's illustrations.

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Fig. c Vitiligo, Fontana stain, medium power. Fontana stain reveals the absence of melanin pigment in basal layer keratinocytes, changes typical of vitiligo. Fig. d Vitiligo, Fontana stain, medium power. In contrast, in a biopsy specimen of normal skin, the Fontana stain highlights the melanin pigment, which stains black in the basal layer keratinocytes. 15 References 1. Frost P, Van Scott EJ. Ichthyosiform dermatoses. Arch Dermatol 1966;94:113. 2. Zhong W, Cui B, Zhang Y, et al. Linkage analysis suggests a locus of ichthyosis vulgaris on 1q22.

The epidermis (keratinocytes) may proliferate without extension into the dermis, extend into the dermis, and may be squamous or basaloid. Melanocytes within the epidermis may proliferate with or without cytologic atypia (nevi, dysplastic nevi, melanoma in situ), in a proliferative epidermis (superficial spreading melanoma in situ, Spitz nevi), or in an atrophic epidermis (lentigo maligna); they can also extend into the dermis as proliferative infiltrates (invasive melanoma with or without vertical growth phase [VGP]).

It may occur on exposed or unexposed skin and in pigmented or poorly pigmented skin. It may be caused on exposed skin by exposure to the sun and on unexposed skin by the ingestion of arsenic. Clin. Fig. a Actinic keratosis. Scaly erythematous macules and papules with a “sandpaper― texture appear commonly on face and dorsal hands, areas subject to chronic sun exposure. Fig. a Hypertrophic actinic keratosis, low power. There is hyperkeratosis alternating with parakeratosis and irregular thickening of the epithelium.

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