By Matthias Dehmer, Frank Emmert-Streib

"Many difficulties from the lifestyles sciences could be forged right into a mathematical framework that's in response to a graph theoretic description. hence an intensive figuring out of such equipment is more and more very important for the knowledge research and modeling of biochemical, organic and biomedical problems." "This booklet follows a brand new method together with graph thought from a mathematical viewpoint through learning functions of Read more...

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Follows a brand new procedure of together with graph concept from a mathematical viewpoint with particular functions of graph idea in biomedical and computational sciences. Of ever expanding significance Read more...

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2007) Irreversible cell cycle transitions are due to systems-level feedback. Nat. , 9 (7), 724–728. , Uhlmann, F. (2009) Irreversibility of mitotic exit is the consequence of systems-level feedback. Nature, 459 (7246), 592–595. F. (2000) Checkpoints controlling mitosis. BioEssays, 22 (4), 351–363. M. (2001) Cell cycle checkpoint genes and aneuploidy: 48 49 50 51 52 53 54 55 56 57 58 59 a short review. Curr. Genomics, 2 (2), 171–180. M. (2000) Manipulating the human embryo: cell cycle checkpoint controls.

BioEssays, 28 (1), 9–22. , Tjian, R. (2003) Transcription regulation and animal diversity. Nature, 424, 147–151. Huang, S. (2004) Back to the biology in systems biology: what can we learn from biomolecular networks? Brief. Funct. Genomic. , 2 (4), 279–297. Dufva, M. ) (2009) DNA Microarrays for Biomedical Research, Methods in Molecular Biology, Vol. 529, Humana Press. , Ren, B. (2010) Next-generation genomics: an integrative approach. Nat. Rev. , 11 (7), 476–486. , Song, O. (1989) A novel genetic system to detect protein-protein interactions.

Showed the metabolic networks of 43 distinct organisms to have a modular organization that was interconnected in a hierarchical manner – a system-level cellular organization that might be generic in nature [91]. The need to investigate the interconnections of genes–proteins and proteins– proteins stems from the fact that the genome of various species is quite similar, despite it having been argued that the evolution of ever more-complex species is correlated with an increased functional connectivity between a constant number of genes.

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