By Summer Research Institute on Algebraic Geometry, Spencer J. Bloch, C. Herbert Clemens

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Extra info for Algebraic Geometry: Bowdoin, 1985, volume: 46 part 2 (Proceedings of Symposia in Pure Mathematics)

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E. Haber, this SERIES). The major recombinase of general DSB repair, Rad51, does not cause interference with additional crossover events, although it can efficiently drive meiotic crossing-over in the absence of Dmc1. Other proteins interacting with Dmc1 in the interference-prone crossover pathway include Rdh54 (the presumptive processivity factor; Sect. 5), as well as the Hop2–Mnd1 complex, which appears to link this pathway to the proper establishment of homolog synapsis. 22 The interferenceprone pathway requires Msh4–Msh5 and, to a lesser extent, Mlh1–Mlh3, whereas the non-interference pathway requires Mus81–Mms4 (Argueso et al.

E. Haber, this SERIES). 20 They have only been revealed by painstaking 19 As mentioned before, the accidental lack of chiasmata would bear a high risk of meiotic nondisjunction. 20 At the extremes, all crossovers in S. pombe are without interference, while in Caenorhabditis elegans they all do show interference. Meiotic Crossing-Over and Disjunction 19 analyses of various mutants, where one or the other pathway is affected differentially. It has long been known from genetic experiments that most gene conversion events that are not associated with a crossover do not cause interference on other crossovers in the vicinity.

1997), now termed condensin I. Further studies have shown that condensin complexes and topo II are interdependent for their association to chromosomes, and both appear as a longitudinal axis along each metaphase chromatid in different species (Coelho et al. 2003; Hudson et al. 2003; Maeshima and Laemmli 2003). Recently, a second condensin complex, condensin II, has been characterized (Ono et al. 2003). Interestingly, the condensin I and II complexes appear at different times during chromosome condensation, and at alternating subdomains along each metaphase chromatid (Ono et al.

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